Publications


2013


  1. Weston LA, Bauer KM, Skube SB, Hummon AB.  “Selective, bead-based global peptide capture using a bifunctional crosslinker”.  Anal Chem.  In Press.

  2. Weston LA, Hummon AB. "Comparative LC-MS/MS analysis of Optimal Cutting Temperature (OCT) compound removal for the study of mammalian proteomes". Analyst.  In Press.

  3. Keithley RB, Weaver EM, Metzinger MP, Rosado AM, Hummon AB, Dovichi NJ. “Single Cell Metabolic Profiling of Tumor Mimics.” Anal Chem. 2013 Sep 6. [Epub ahead of print]

  4. Yue XS, Hummon AB. "Combination of Multi-Step IMAC Enrichment with High-pH Reverse Phase Separation for In-Depth Phosphoproteomic Profiling".  Journal of Proteome Research. 2013 Sep 6;12(9):4176-86.

  5. Weston LA*, Bauer KM*, Hummon AB. "Comparison of bottom-up proteomic approaches for LC-MS analysis of complex proteomes".  Analytical Methods, 2013, 5 (18), 4615 - 4621.

  6. Liu, X, Weaver EM, Hummon AB."Evaluation of Therapeutics in Three-Dimensional Cell Culture Systems by MALDI Imaging Mass Spectrometry".  Analytical Chemistry, 2013 Jul 2;85(13):6295-302. Epub 2013 Jun 11.

  7. Hummon, A.B.; Dovichi, N.J. “The Tools of Proteomics” The Analytical Scientist, 2013, 1, 413-420. 

  8. Dovichi NJ, Hummon AB. "The Tools Behind Genomics" The Analytical Scientist, 2013, 1, 24-31.

  9. Weaver EM, Hummon AB. "Imaging mass spectrometry: from tissue sections to cell cultures" Advanced Drug Discovery Reviews, 2013 Jul;65(8):1039-55.


2012


  1. Yue XS, Hummon AB. "Mass spectrometry-based phosphoproteomics in cancer research." Front. Biol. 2012, 7(6): 566–586.

  2. Bauer KM, Hummon AB. “Effects of the miR-143/-145 MicroRNA Cluster on the Colon Cancer Proteome and Transcriptome.” J Proteome Res. 2012 Sep 7;11(9):4744-54.

  3. Bauer KM, Lambert PA, and Hummon AB. "Comparative label-free LC-MS/MS analysis of colorectal adenocarcinoma and metastatic cells treated with 5-fluorouracil"  Proteomics 2012, 12, 1-10

  4. Hummon AB, Pitt JJ, Camps J, Emons G, Skube SB, Huppi K, Jones TL, Beissbarth T, Kramer F, Grade M, Difilippantonio MJ, Ried T and Caplen NJ. "Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells"  Molecular Cancer 2012, 11:1.

  5. Bauer, K.M.; Hummon, A.B.; Buechler, S. “Right-side and left-side colon cancer follow different pathways to relapse.” Mol Carcinog., 2012 May; 51(5);411-21.


2011


  1. Li H, Hummon AB. “Imaging mass spectrometry of three-dimensional cell culture systems.” Anal Chem. 2011 Nov 15;83(22) 8794-801.


Post Doc and Graduate Training


  1. Padilla-Nash HM, McNeil NE, Yi M, Nguyen QT, Hu Y, Wangsa D, Mack DL, Hummon AB, Case C, Cardin E, Stephens R, Difilippantonio MJ, Ried T. Aneuploidy, Oncogene Amplification, and Epithelial to Mesenchymal Transition Define Spontaneous Transformation of Murine Epithelial Cells."Carcinogenesis. 2013 In Press

  2. Camps J, Pitt JJ, Emons G, Hummon AB, Case CM, Grade M, Jones TL, Nguyen QT, Ghadimi BM, Beissbarth T, Difilippantonio MJ, Caplen NJ, Ried T. ”Genetic Amplification of the NOTCH Modulator LNX2 Upregulates the WNT/β-Catenin Pathway in Colorectal Cancer.” Cancer Res. 2013 Mar 6. 

• Grade, M.; Hummon, A.B.; Emons, G.; Camps, J.; Spitzner, M.; Hoermann, P.; Gaedcke, J.; Ebner, R.; Becker, H.; Ghadimi, B.M.; Beissbarth, T.; Difilippantonio, M.J.; Caplen, N.J.; Ried, T. “Identification and Validation of NOL5A and RPS2 as Potential Therapeutic Targets in Colorectal Cancer using a Functional Genomics Approach.” Int J. Cancer. March 2011 128(5):1069-79.

• Camps, J.; Nguyen, Q.T.; Padilla-Nash, H.M.; Knutsen, T.; McNeil, N.E.; Wangsa, D.; Hummon, A.B.; Grade, M.; Ried, T.; Difilippantonio, M.J. “Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer.” Genes Chromosomes Cancer. 48, 1002 (2009).

• Camps, J.; Grade, M.; Nguyen, Q.T.; Hörmann, P.; Becker, S.; Hummon, A.B.; Rodriguez, V.; Chandrasekharappa, S.; Chen, Y.; Difilippantonio, M.J.; Becker, H.; Ghadimi, B.M.; Ried, T. “Chromosome breakpoints in primary colon cancer cluster at sites of structural variants in the genome.” Cancer Res. 68, 1284 (2008).

• Hummon, A.B.; Martin, S.E.; Caplen, N.J. “RNAi screens: Going right to the target.” Screening-Trends in Drug Discovery 4, 2 (2007).

• Hummon, A.B.; Lim, S.R.; Difilippantonio, M.J.; Ried, T. “Isolation and solubilization of proteins after TRIzol extraction of RNA and DNA from patient material following prolonged storage.” Biotechniques 42, 467 (2007).

• Grade, M.; Hörmann, P.; Becker, S.; Hummon, A.B.; Wangsa, D.; Varma, S.; Simon, R.; Liersch, T.; Becker, H.; Difilippantonio, M.J.; Ghadimi, B.M.; Ried, T. “Gene Expression Profiling Reveals a Massive, Aneuploidy-Dependent Transcriptional Deregulation and Distinct Differences between Lymph Node Negative and Positive Colon Carcinomas.” Cancer Res. 67, 41 (2007).

• Hummon, A.B.; Richmond, T.A.; Amare, A.; Ewing, M.A.; Verleyen, P.; Baggerman, G.; Schoofs, L.; Southey, B.; Rodriguez-Zas, S.L.; Robinson, G.E.; Sweedler, J.V. “From the Genome to the Proteome: Uncovering Peptides in the Apis Brain.” Science 314, 647 (2006).

• The Honeybee Genome Sequencing Consortium. "Insights into social insects from the genome of the honeybee Apis mellifera." Nature 443, 931 (2006).

• Amare, A.; Hummon, A.B.; Southey, B.R.; Zimmerman, T.A.; Rodriguez-Zas, S.L.; Sweedler, J.V. “Bridging Neuropeptidomics and Genomics with Bioinformatics: Prediction of Mammalian Neuropeptide Prohormone Processing.” J. Proteome Res. 5, 1162 (2006).

• Hummon, A.B.; Amare, A.; Sweedler, J.V. “Discovering New Invertebrate Neuropeptides using Mass Spectrometry.” Mass Spectrom. Rev. 25, 77 (2006).

• Stuart, J.N.; Hummon, A.B.; Sweedler, J.V. “The Chemistry of Thought: Neurotransmitters in the Brain.” Anal. Chem. 76, 121A (2004).

• Cummins, S.F.; Nichols, A.; Amare, A.; Hummon, A.B.; Sweedler, J.V.; Nagle, G.T. “Novel Candidate Protein Pheromones in Aplysia: Identification, Characterization, Expression, and Biological Activity.” J. Biol. Chem. 279, 25614 (2004).

• Page, J.S.; Hummon, A.B.; Sweedler, J.V. “Single Cell Peptide Analysis with MALDI-MS” for Encyclopedia of Mass Spectrometry. Vol 2, Biological Applications. Eds. R. Caprioli and M. Gross. 2004.

• Hummon, A.B.; Hummon, N.P.; Corbin, R.W.; Li, L.; Vilim, F.S.; Weiss, K.R.; Sweedler, J.V. “From Precursor to Final Peptides: A Statistical Sequence-Based Approach to Predicting Prohormone Processing.” J. Proteome Res. 2, 650 (2003).

• Hummon, A.B.; Corbin, R.W.; Sweedler, J.V. “Discovering New Neuropeptides using Single Cell Mass Spectrometry.” Trends Anal. Chem. 22, 515 (2003).

• Hummon, A.B.; Huang, H.; Kelley, W.P.; Sweedler. J.V. “A Novel Prohormone Processing Site in Aplysia californica: the Leu-Leu Rule.” J. Neurochem. 82, 1398 (2002).