Current Funding and Research Positions Available

Current Research Funding

Current research funding derives from three sources: The National Science Foundation (NSF), the National Institutes of Health (NIH), and Omicron Biochemicals Inc.. An NIH R21 project has been approved for funding (budget and start date are presently unknown.

• National Science Foundation (1402744)

  Conformational Equilibria of Biologically Relevant Oligosaccharides. Principal Investigator: Anthony S. Serianni. CoPIs: Ian Carmichael (Notre Dame), Robert Woods (Georgia). Total Cost: $750,000. Start Date: August 1, 2014. End Date: July 31, 2017. This project will develop new NMR-based tools to investigate oligosaccharide conformations in aqueous solution.

  
  
• National Institutes of Health/SBIR (1R43HD083975-01)

  Large Scale Synthesis of N-Acetyl-Lactosamine and HMO Oligosaccharides. Principal Investigator: Qingfeng Pan (Omicron). Consultant: Anthony S. Serianni (President/CEO, Omicron). Total Cost: $150,000. Start Date: April 1, 2015. End Date: September 30, 2015. This project will develop synthetic methods (chemical and chemo-enzymic) to prepare human milk oligosaccharides (HMOs) on a large (kilogram) scale under cGMP conditions to support anticipated clinical trials in humans.

  
  
• Indiana Economic Development Corporation

  Indiana 21st Century Research and Technology Fund. Grant supplement to NIH SBIR Phase I 1R43HD083975-01, $50,000. Receipt of funds pending (07/20/15).

  
  
• National Institutes of Health: 1 R21 CA199745-01

  Solid-State NMR and J-Coupling in Saccharides: New Tools for Structure Analysis. Principal Investigator: Anthony S. Serianni. CoPI: Dr. Wenhui Zhang, University of Notre Dame. Total Direct Cost: $600,200 (two years). Submitted: December 1, 2014. This NMR project aims to develop new solid-state methods to investigate J-couplings in solids and to characterize saccharide bound conformations in biological receptors.

Undergraduate Research Positions

Positions are available for 1-2 undergraduate research assistants per academic year. Summer research stipends are also occasionally available. Please contact Professor Serianni for more information (phone: 574-631-7807; fax: 574-631-6924; email: aseriann@nd.edu).

Postdoctoral Positions

The laboratory is currently accepting applications for two postdoctoral positions to support work on the above-mentioned NSF and NIH projects (see following advertisement). Please contact Professor Serianni for more information (phone: 574-631-7807; fax: 574-631-6924; email: aseriann@nd.edu).

Structural Studies of Oligosaccharides. Two postdoctoral positions are available immediately in the area of oligosaccharide structure determination. Successful candidates will have PhD-level training in oligosaccharide synthesis (chemical/enzymic), NMR/X-ray crystallography and/or computational chemistry (electronic structure/MD). Experience with isotopic labeling is desirable. Send curriculum vitae to: Prof. Anthony S. Serianni, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556-5670 (aseriann@nd.edu; www.nd.edu/~aseriann). The University of Notre Dame is an equal-opportunity/affirmative action employer.