The Notre Dame Bioinformatics Laboratory focuses on computational genomics and its application to global health and ecology research. What distinguishes our work is its collaborative and interdisciplinary nature for solving non-model genome bioinformatics problems. We have been at the leading edge of related data-intensive technologies such as high-throughput sequencing and cloud computing, both active areas of our research.
Currently, we are heavily involved in arthropod genomics in collaboration with multiple faculty members in the Department of Biological Sciences at Notre Dame. Most of this work is focused on Anopheles vectors (e.g., An. gambiae M and S forms, shown on right) housed in our NIH/NIAID Bioinformatics Resource center VectorBase. We are also substancially involved in the Anopheles and Daphnia genome consortiums.
A common theme in our research is deriving long-range computational
problems in the process helping our colleagues with their short-term
bioinformatics needs. Most of this work centers on non-model
organism "draft" sequences that are likely to never be finished
(e.g., Anise swallowtail, shown on left). We are currently developing tools
and software systems for fragmented assemblies, especially
those derived from ecological samples, which are made available here.
New! Show off your NDBL support with T-shirts and other items designed by PhD alum Shawn O'Neil.