The research team in the Hoelzle Research Lab (HRL) investigates emerging control laws for application to myriad manufacturing problems. Broadly classified, we are interested in high-value added microscale manufacturing applications with impacts in both human health and sensor technology. The key applications are engineered synthetic tissues, microfluidic devices for the sorting and enrichment of cells with a targeted phenotype, and microscale electrical and electro-optic circuits. Our key expertise lies in learning-based control algorithms, sensor development, and system design.
New to research that involves microfluidic devices and want to get up and running fast? Our lab has posted our complete protocol that details every step from device conception to finished chip testing.
|GRADUATION DATE||CURRENT EMPLOYER / INSTITUTION|
|A. James Schmidt||May 2014||
Dept. of Electrical and Computer Engineering
|Joe Williams||May 2013||Phillips Medisize|
There are traditional ‘old-guard’ technologies for the manufacture of engineered tissues, microfluidic devices, and electrical and electro-optical circuits: Beyond autologous tissue and allogeneic tissue transplantation, widely accepted engineered synthetic tissues are manufactured in bulk with a generic form factor and a randomly distributed, hence non-specific, microstructure; Microfluidic devices manufactured by soft-lithography are largely passive devices with ex situ actuation, hence actuation lag; Electronic and electro-optical circuits manufactured by lithographic micromachining are not reconfigurable without capital investment. We, at the HRL, design advanced control laws and sensored and actuated systems to overcome some of the short-comings of the ‘old-guard’ manufacturing technologies - with the motivation of more specific and targeted therapeutic treatments and less expensive communication circuits.
We believe that developing manufacturing systems for improving human health and inexpensive optical networks are just and worthwhile research endeavors. However, beyond the societal implications of such research, we leverage a multi-disciplinary toolset that continually exposes members of the HRL to emerging research in biology, micro/nano-technology and systems integration; broad exposure gives us interesting and just plain cool toys to work with. For some HRL members, their mornings may be spent in Notre Dame’s Class 100 cleanroom in the new Stinson-Remick building and the afternoon in the bio-hood collaborating with cell biologists to test a new device on live cancer cells. As a PI, I believe that interesting technologies and clearly constructed objectives and rationales are the best way to motivate students. I do not demand results or count the hours spent in lab, instead I believe it is my job to construct projects that are so engaging that the results just happen. Not every day will be outstanding – you have to solder up an op-amp if you want to control a high-speed oscillator in a microfluidic device – but my hope is that the mundane will be worthwhile when the student is engrossed in accomplishing the ultimate objective.
Autogolous bone grafts - bone grafts harvested and then transplanted into the same patient - are the 'gold standard' in tissue regeneration for the treatment of bone defects. However, there are many complications - including lack of supply and donor site pain / morbidity - that make autogolous bone solutions sub-optimal. We are developing bioceramic synthetic scaffolds - synthetic extracellular matrices that support bone remodeling - that are biocompatible and can be designed on both the macroscopic and microscopic level. Scaffolds are fabricated using an AM system that is particularly adept at fabricating porous ceramic structures, micro-Robotic Deposition. Current research thrusts are the development of near-net shape structures and improvement of fabrication accuracy through advanced controls.
ILC is a control methodology that exploits process repetition to achieve extremely precise trajectory tracking. ILC is best applied to mass manufacturing problems where repeated trajectories are common. Similarly, AM systems employ repeated trajectory sub-components, or motion primitives. In constrast, AM systems are flexible manufacturing systems in which their usefulness is derived from their ability to change the fabricated part, hence trajectory, from part to part. Current research investigates modifications to ILC for AM at the microscale, to enable precise trajectory tracking, but in a control formulation that allows for continual and facile rearrangements of trajectories.
Microfluidic devices have become an established tool for biological studies of single cells or tissues. By exploiting the physics of flow at the microscale we can specifically tailor experiments in ways that were previously impossible. However, the majority of microfluidic devices are static in that the channels do not move. We are investigating in situ actuators within microfluidic devices to perturb cells and tissue.
D.J. Hoelzle, "Flexible Adaptation of Iterative Learning Control with Applications to Synthetic
Bone Graft Manufacturing," University of Illinois at Urbana-Champaign, Urbana, IL, 2011 Download
D.J. Hoelzle, "Reliability Guidelines and Flwrate Modulation for a Micro Robotic Deposition
System," University of Illinois at Urbana-Champaign, Urbana, IL, 2007 Download
July 13, 2015: Two projects from Notre Dame involving faculty members Prof. Hoelzle, Prof. Steven Schmid, and Prof. Rick Billo have been funded by America Makes. The HRL is looking for strong post-doc applicants for one of the projects.
July 1, 2015: Both on the same day, Preetham wins the Engineering Novel Solutions to Cancer's Challenges at the Interdisciplinary Interface (ENSCCII) fellowship from the Walther Cancer Foundation (renewable up to three years) and Mindy wins the Berry Fellowship from the Advanced Diagnostics and Therapeutics Initiative. Congrats and nice work to both!
July 1, 2015: The lab welcomes three members to the lab. Dr. Preetham Burugupally will be the lab's first post-doc and comes to us from the University of Kansas. Stephen Bedard is a new graduate student who received his undergraduate degree in Mechanical Engineering from Notre Dame. Santiago Martinez is joining us an undergraduate researcher from Notre Dame.
April 18, 2015: The business plan team from the University of Notre Dame, Enlightened Diagnostics, wins $19,000 at the Rice Business Plan Competition. Enlightened Diagnostics is a spin-off company from research generated in the HRL and the labs of Dr. Jeremy Zartman (Notre Dame Dept. Chemical and Biomolecular Engineering) and Dr. Siyuan Zhang (Notre Dame Dept. of Biological Sciences).
April 13, 2015: Dr. Hoelzle wins a $30,000 seed grant from the American Cancer Society Institutional Research Grant and the Harper Cancer Research Institute.
February 27, 2015: Max Kennard wins the NDnano Undergraduate Research Fellowship.
September 23, 2014: The research team of Dr. Hoelzle, Dr. Jeremy Zartman (Notre Dame Dept. Chemical and Biomolecular Engineering), and Dr. Siyuan Zhang (Notre Dame Dept. of Biological Sciences) wins a $30,000 seed grant from the Advanced Diagnostics and Therapeutics Initiative.
September 2, 2014: Two new undergraduate researchers Jacob Bur and John Castellini join the lab. Welcome!
August 18, 2014: The lab welcomes new graduate students Thomas Storey and Dewen Yushu! Thomas graduated with his bachelors in Mechanical Engineering from the University of Portland and Dewen graduated with her bachelors in Materials Science from Huazhong University of Science and Technology.
July 22, 2014: The research team of Dr. Hoelzle and Dr. Kira Barton (Dept. of Mechanical Enigneering, University of Michigan) is awarded a grant from the NSF CMMI Sensors, Dynamics, and Control program.
May 20, 2014: The research team of Dr. Jeremy Zartman (Notre Dame Dept. Chemical and Biomolecular Engineering), Dr. Hoelzle, and Dr. Mark Alber (Notre Dame Dept. of Applied and Computational Mathematics and Statistics) is awarded a grant from the NSF CBET Biotechnology, Biochemical, and Biomass Engineering program.
May 18, 2014: Undergraduate researcher James Schmidt graduates from Notre Dame with a triple major in Mathematics, Mechanical Engineering, and Philosophy. Congrats! James will start a Ph.D. program in Electrical and Computer Engineering at the University of Illinois Urbana-Champaign in the Fall.
May 12, 2014: Max Kennard joins the lab as an undergraduate researcher. Welcome!
January 14, 2014: Jay Dawahare joins the lab as an undergraduate researcher. Welcome!
September 12, 2013: Two undergraduate researchers, Danny Muldoon and Peter Nguyen, join the lab. Welcome!
September 5, 2013: James Schmidt joins the lab as an undergraduate researcher. Welcome!
May 19, 2013: Joe Williams graduates with his Bachelors degree from the Dept. Aerospace and Mechanical Engineering. He will start at Phillips Medisize after traveling around Europe this summer.
May 17, 2013: Dr. Hoelzle receives the Dept. of Aerospace and Mechanical Engineering Award for Excellence in Teaching for the Spring 2013 Semester.
February 4, 2013: Two more undergraduate researchers, Matthew Nagy and Sebastian Ortega, join the lab. Welcome!
December 28, 2012: Inaugural members Julia Concelman, Jacob Pellegrini, and Joseph Williams join the lab.
December 1, 2012: The Hoelzle Research Lab is officially established. Many productive years ahead!
Please direct all requests to Dr. Hoelzle:
141 Multidisciplinary Research Building
Dept. of Aerospace and Mechanical Engineering
University of Notre Dame
Notre Dame, IN 46556
Ph: (574) 631-2291
dhoelzle at nd dot edu
The HRL is currently hiring one post-doc to study the design, fabrication, and automation of an on-Chip system for 3D, multiplexed imaging of living and fixed tissues and organisms. Applications details can be found here.
Dr. Hoelzle receives multiple requests a day regarding sponsored graduate work. Only students who have applied to the University of Notre Dame will be considered. If you have applied, please state that you "have applied to the Dept. of X Engineering" in the first line of your email, where X is the relevant Department.
Please email Dr. Hoelzle a statement of your research interests and a current resumé. This information will facilitate a discussion of possible research projects.