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Aedes aegypti Genome
Severson Lab

My laboratory has broad interest in mosquito genetics and genomics, with a primary goal of understanding the molecular genetics of disease transmission by mosquitoes. Most of our work involves the Yellow Fever and Dengue Fever virus vector Aedes aegypti. This has included development of genetic markers and the genetic dissection of phenotypes associated with competence to transmit pathogens to vertebrates. At present, the pathogen we work with is dengue virus, with a focus on whole transcriptome responses of the mosquito host to infection. Other pathogens we have worked with previously include the human lymphatic filariasis parasite Brugia malayi, and the avian bird malaria Plasmodium gallinaceum. We have a long standing collaboration on field studies in Trinidad with Dr. Dave Chadee at the University of the West Indies. We also played a significant role in the Aedes aegypti Genome Project.

We have conducted additional studies with the Asian Tiger mosquito Aedes albopictus, the West Nile virus vector Culex pipiens, and the LaCrosse virus vector Ochlerotatus triseriatus. Phenotypes of interest have included vector competence, autogeny, diapause, meiotic drive and several life history traits.

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To contact us: my email my office phone (574-631-3826); my lab phone (574-631-4151); FAX (574-631-7413); Mail Address: 107C Galvin Life Sciences, University of Notre Dame, Notre Dame, IN 46556.