Hyde Lab: Yiying Luo

Graduate Student

2002	Fudan University Shanghai, China	B.S. Biology
Present	University of Notre Dame, Center for Zebrafish Research	Doctoral Student
	Project:
	under David R. Hyde

My studies focus on the basolateral cell polarity gene scribble’s function in retinal lamination pattern in the zebrafish. The vertebrate retina develops from a single sheet of multipotent neuroepithelial cells into a mature tissue that is composed of Müller glia and six major classes of neurons. In the differentiated retina, individual cell classes are organized into distinct laminae (layers) that have separate functions. We determined that loss of Scribble function resulted in defects in neuroepithelial cell differentiation and laminar pattern. These defects appear to be due to the neuroepithelial cells failing to properly exit the cell cycle and beginning differentiation.

Refereed Manuscripts

1. Wei, X., Luo, Y., and Hyde, D.R. (2006). Molecular cloning of three zebrafish lin7 genes and their expression patterns in the retina. Exp. Eye Res. 82:122-131.

2. Shi, X., Luo, Y., Howley, S., Dzialo, A., Foley, S., Hyde, D.R., and Vihtelic, T.S. (2006). Zebrafish foxe3: roles in lens morphogenesis through interaction with pitx3. Mech. Dev. 123:761-82.

3. Wei X, Cheng Y, Luo Y, Shi X, Nelson S, Hyde D.R. (2004). The zebrafish Pard3 ortholog is required for separation of the eye fields and retinal lamination. Dev Biol 269(1):286-301.