to the Center
in a quantitative and predictive way the complex patterns and organization
that arise in living organisms at length scales from molecular to
to prepare undergraduate, graduate and postdoctoral students for the
challenges of twenty-first century biology, which require a merging
of fundamental biological understanding and methods with physical,
computational, and mathematical approaches.
to become a true Center for the study of Biocomplexity at the national
and international level, providing opportunities to study and disseminate
both experiment and theory at all levels. One of our main goals is
to improve communication between biological, mathematical and physical
and resources: to develop techniques and tools of broad utility
to bioscientists and to distribute these freely to the community at
Our long-term goal
is to develop comprehensive multiscale models of cell and tissue organization
and their relation to development. We address three scales of structure,
starting from the level of genetic control networks and including at the
subcellular level molecular machines and cytoskeletal and protein networks.
At the cell level, we emphasize cell polarity and cell-cell interactions.
At the supercellular level, our studies include the aggregation of cells
into tissues and tissues into organs.
All projects combine
quantitative experiments and computer simulations and build on the mutually
complementary strength of the researchers at Notre Dame with support from
our collaborators at other institutions.
2003 Issue of`"The Biological Physicist," ICSB Profile (PDF)