In Computing at the Nanoscale, we will investigate what computer architectures and new applications emerging technologies might enable. We will begin by addressing challenges to current CMOS scaling (at both the device and architectural levels) and consider how an end to Moore's Law might impact application-level performance and (b) what industry is doing to "extend CMOS" and continue the performance scaling trends that we have come to expect for the last 30+ years beyond the year 2020. (Techniques such as 3D integration will be introduced and their architectural impact will be assessed.) We will then look at how new devices (i.e. emerging technologies) might help us to improve the performance of future computational systems as well as what new applications might be enabled with new devices. In class, we will discuss not only how a new device works, but also how new ways of representing 1s and 0s will ultimately affect systems-level structures.