Multi-Scale Cardiovascular Bioengineering Laboratory

The Multi-Scale Cardiovascular Bioengineering Laboratory (MSCBL) at Notre Dame was established in August 2008 by Dr. Philippe Sucosky in the Department of Aerospace and Mechanical Engineering. The MSCBL is located in the Multidisciplinary Research Building and is part of the Bioengineering Graduate Program.

LAB MISSION

The MSCBL aims at elucidating the complex relations between cardiovascular tissue biology and the surrounding hemodynamic environment, at the gene, cell and tissue levels. The knowledge of such relations will guide the development of early medical interventions for the treatment of degenerative and congenital cardiovascular disorders.

VISION STATEMENT

The MSCBL applies state-of-the art engineering techniques to solve challenges in the cardiovascular field. The research conducted in the MCBL adopts an integrative approach to:

1- understand the complications caused by congenital and degenerative cardiovascular disorders

2- optimize the tissue engineering of functional heart valve substitutes

3- predict cardiovascular tissue remodeling and disease progression from a fluid mechanical perspective.

In this highly interactive research program, the knowledge of the flow characteristics in different cardiovascular disorder configurations and the identification and prediction of the mechanobiological pathways leading to those disorders will guide the development of early medical interventions for the treatment of cardiovascular pathologies.