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Kamlesh Gupta , PhD
Senior Scientist
University of Notre Dame

Education

MS, RML University (India), 2000

PhD, Indian Institute of Technology, Bombay (India), 2005

Post-doctoral fellow, University of Notre Dame, 2006-2010

Post-doctoral fellow, Boston Children's Hospital, Harvard Medical School, 2010-2011

Address
W. M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall
University of Notre Dame
Notre Dame, IN 46556

Contact
Phone: (574) 631-2320
Fax: (574) 631-4048
E-mail: Kamlesh.K.Gupta.19@nd.edu

Honors and Awards

2008-2009: American Heart Association (AHA) postdoctoral fellowship (Midwest affiliate)  

2006: Dr. Gargi Vishnoi Best Ph.D. student Award IIT Bombay, Mumbai, INDIA 

2000-2005: Graduate Fellowship, Ministry of Human Resource Development, INDIA

2000-2001: Teaching Assistant, School of Biosciences & Bioengineering, IIT Bombay, Mumbai, INDIA

Memberships and Committees

2009-2010: Reviewer, Biochemistry, Journal of Cell Science, Cancer Chemotherapy and Pharmacology 

2006-2009: American Society for Cell Biology (ASCB)

2003: Indian Society for Cell Biology

2002: Indian Association for Cancer Research (IACR)

Research Interests

My current research focuses on understanding the regulation of the fibrinolytic system in physiological processes, and the mechanism by which defect in the fibrinolytic pathway leads to sepsis and other inflammatory diseases.

Selected Recent Publications

*Gupta KK, Li C, Duan AR, Alberico EO, Kim OV, Alber MS, and Goodson HV. A mechanism for the catastrophe-promoting activity of the microtubule destabilizer Op18/stathmin. Proc. Natl. Acad. Sci. USA (2013) in press (*Corresponding author).

Karna P, Rida PC, Pannu V, Gupta KK, Dalton WB, Joshi H, Yang VW, Zhou J, and Aneja R. A novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering. Cell Death Differ. (2011) 18: 632-644.   

Gupta KK, Joyce MV, Slabbekoorn AR, Zhu ZC, Paulson BA, Boggess B and Goodson HV. Probing interactions between CLIP-170, EB1, and microtubules. J. Mol. Biol. (2010) 395: 1049-1062.

Gupta KK, Paulson BA, Folker ES, Charlebois B, Hunt AJ and Goodson HV. The minimal plus-end tracking unit of the cytoplasmic linker protein CLIP-170. J. Biol. Chem. (2009) 284: 6735-6742.

Zhu ZC, Gupta KK, Slabbekoorn AR, Paulson BA, Folker ES and Goodson HV. Interactions between EB1 and microtubules: dramatic effect of affinity tags and evidence for cooperative behavior. J. Biol. Chem. (2009) 284: 32651-32661.

Gupta KK, Bharne SS, Rathinasamy K, Naik NR and Panda D. Dietary antioxidant curcumin inhibits microtubule assembly through tubulin binding. FEBS J. (2006) 273: 5320-5332.

Gupta K, Bishop J, Peck A, Brown J, Wilson L and Panda D. Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin. Biochemistry (2004) 43: 6645-6655.

Zhou J, Gupta K, Aggarwal S, Aneja R, Chandra R, Panda D and Joshi HC. Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation. Mol. Pharmacol. (2003) 63: 799-807.

Gupta K and Panda D. Perturbation of microtubule polymerization by quercetin through tubulin binding: a novel mechanism of its antiproliferative activity. Biochemistry (2002) 41: 13029-13038.

Zhou J, Gupta K, Yao J, Ye K, Panda D, Giannakakou P and Joshi HC. Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine. J. Biol. Chem. (2002) 277: 39777-39785.

 

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