Associate Professor, Division of Molecular Genetics
and Gene Therapy
Department of Medical and Molecular Genetics
Indiana University School of Medicine
BA, Columbia University, 1969
PhD, University of Iowa, 1980
Postdoctoral fellow, University of California,
San Diego, 1980-1984
Phone: (317) 278-6125
975 W. Walnut St.
Indianapolis, IN 46202
Dr. Rosen’s research interests focuses on determining the physiological consequences of genetic deficiencies of coagulation and anticoagulation genes in mice. One focus examines the role of these genes in clot development and hemostasis utilizing a number of vascular injury models. Additionally, since several coagulation and anticoagulation deficiencies result in embryonic or neonatal death, his laboratory is developing strategies of rescuing these mice through in utero transplantation of liver progenitor cells.
Selected Recent Publications
Rosen ED, Xuei X, Suckow M, Edenberg H. (2006). Searching for hemostatic modifier genes affecting the phenotype of mice with very low levels of FVII. Blood Cells Mol Dis. 36:131-134.
Suckow MA, Zollman A, Cornelissen I, Casad M, Roahrig J, Castellino FJ, Rosen ED. (2005). Tissue distribution of fetal liver cells following in utero transplantation in mice. Exp Biol Med (Maywood). 230:860-864.
Rosen ED, Xu H, Liang Z, Martin A, Suckow M, Castellino FJ. (2005). Generation of genetically-altered mice producing very low levels of coagulation factor VII. Thromb Haemost.94:493-497.
Lay AJ, Liang Z, Rosen ED, Castellino FJ. (2005). Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities. J Clin Invest. 115:1552-1561.
Rosen Ed, Cornelissen I, Suckow M, Zollman A, Liang Z, Casad M, Roahrig J, Castellino FJ. (2003). In utero transplantation of fetal liver cells rescues factor X deficient mice from perinatal lethality. J Thromb Haemost.1:19-27.