Core Manager, Molecular Biology
Associate Professional Specialist
B.S., China Ocean University
Qingdao, P.R. China 1982
M.S., Institute of Tropical Medicine,
Antwerp, Belgium, 1993
W. M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall
University of Notre Dame
Notre Dame, IN 46556
Phone: (574) 631-4192
Fax: (574) 631-4048
Honors and Awards
Leuven University Scholarship, 1994-1997
Belgium Red Cross Fellowship, 1993-1994
Mr. Liang manages the molecular biology core of the W. M. Keck Center for Transgene Research. He is responsible for the design and construction of molecular vectors for the expression of recombinant proteins and for the generation of transgenic and gene modified mice.
Selected Recent Publications
Iwaki T, Malinverno C, Smith D, Xu Z, Liang Z, Ploplis VA, Castellino FJ. (2010) The generation and characterization of mice expressing a plasmin-inactivating active site mutation. J Thromb Haemost. 8:2341-2344.
Sheng Z, Liang Z, Geiger JH, Prorok M, Castellino FJ. (2009) The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B. Neuropharmacology. 57:127-136.
Wei X, Chen X, Fontanilla C, Zhao L, Liang Z, Dodel R, Hampel H, Farlow M, Du Y. (2007). C/T conversion alters interleukin 1A promoter function in a human astrocyte cell line. Life Sci. 27:1152-1156.
Heinrich JE, Pollard M, Wolter WA, Liang Z, Song H, Rosen ED, Suckow MA. (2006). Vaccination against prostate cancer using a live tissue factor deficient cell line in Lobund-Wistar rats. Cancer Immunol Immunother. 56:725-730.
Rosen ED, Xu HF, Liang Z, Martin JA, Suckow M, Castellino FJ. (2005). Generation of gentically-altered mice producing very low levels of coagulation FVII. Thromb Haemost. 94:493-497.
Lay AJ, Liang Z, Rosen ED, Castellino FJ. (2005). Mice with severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities. J Clin Invest. 115:1552-1561.