Publications

  • Gillette M, Bray K, Blumenthaler A, Vargo-Gogola T, (2013) "P190B RhoGAP Overexpression in the Developing Mammary Epithelium Induces TGFb-dependent Fibroblast Activation" PLoS ONE 8(5): e65105. Download.
  • Hwang M, Peddibhotla S, McHenry P, Chang P, Yochum Z, Park KU, Sears JC, Vargo-Gogla T, (2012) "P190B RhoGAP Regulates Chromosome Segregation in Cancer Cells" Cancers 4(2): 475-489. Download.
  • Bray K, Brakebusch C, Vargo-Gogola T, (2011) "The Rho GTPase Cdc42 is required for primary mammary epithelial cell morphogenesis in vitro" Small GTPases 2(5): 1-12. Download.
  • Heckman-Stoddard BM, Vargo-Gogola T, Herrick MP, Visbal AP, Lewis MT, Settleman J, Rosen JM, (2011) "P190A RhoGAP is required for mammary gland development." Developmental Biology (in press). Download.
  • "10 Things I Wish I'd Known Before I Wrote My K99" by Tracy Vargo-Gogola, PhD. Download.
  • McHenry PR, Sears JC, Herrick MP, Chang P, Heckman-Stoddard BM. Rybarczyk M, Chodosh LA, Gunther EJ, Hilsenbeck SG, Rosen JM, Vargo-Gogola T, (2010) "P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis." Breast Cancer Research 12(5): R73. Download.
  • Vargo-Gogola T, (2010) "Putting the brakes on breast cancer: therapeutic opportunities to bring cancer stem cells and the tumor microenvironment to a screeching halt." Current Drug Targets 11(9): 1041-2. Download.
  • McHenry PR, Vargo-Gogola T, (2010) "Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment?" Current Drug Targets 11(9): 1043-58.
  • Lynch CC, Vargo-Gogola T, Matrisian LM, Fingleton B, (2010) "Cleavage of E-Cadherin by Matrix Metalloproteinase-7 Promotes Cellular Proliferation in Nontransformed Cell Lines via Activation of RhoA." Journal Oncology 2010: 530745. Download.
  • Heckman-Stoddard BM, Vargo-Gogola T, McHenry PR, Jiang V, Herrick MP, Hilsenbeck SG, Settleman J, Rosen JM, (2009) "Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression." Breast Cancer Research 11(4): R61. Download.
  • Heckman BM, Chakravarty G, Vargo-Gogola T, Gonzales-Rimbau M, Hadsell DL, Lee AV, Settleman J, Rosen JM, (2007) "Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development." Developmental Biology 309(1): 137-49. Download.
  • Vargo-Gogola T, Rosen JM, (2007) Modelling breast cancer: one size does not fit all." Nature Reviews Canncer 7(9): 659-72. Download.
  • Lynch CC, Vargo-Gogola T, Martin MD, Fingleton B, Crawford HC, Matrisian LM, (2007) "Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor." Cancer Research 67(14):6760-7. Download.
  • Vargo-Gogola T, Heckman BM, Gunther EJ, Chodosh LA, Rosen JM, (2006) "P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland." Molecular Endocrinology 20(6): 1391-405. Download.
  • Xian W, Schwertfeger KL, Vargo-Gogola T, Rosen JM, (2005) "Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model." Journal Cell Biology 171(4): 663-73. Download.
  • Lynch CC, Hikosaka A, Acuff HB, Martin MD, Kawai N, Singh RK, Vargo-Gogola TC, Begtrup JL, Peterson TE, Fingleton B, Shirai T, Matrisian LM, Futakuchi M, (2005) "MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL." Cancer Cell 7(5): 485-96. Download.
  • Vargo-Gogola T, Crawford HC, Fingleton B, Matrisian LM, (2002) "Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand." Archives of Biochemistry and Biophysics 408(2): 155-161. Download.
  • Vargo-Gogola T, Fingleton B, Crawford HC, Matrisian LM, (2002) "Matrilysin (matrix metalloproteinase-7) selects for apoptosis-resistant mammary cells in vivo." Cancer Research 62(19): 5559-63. Download.
  • Fingleton B, Vargo-Gogola T, Crawford HC, Matrisian LM, (2001) "Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosis." Neoplasia 3(6): 459-68. Download.
  • De Rocher EJ, Vargo-Gogola TC, Diehn SH, Green PJ, (1998) "Direct evidence for rapid degradation of Bacillus thuringiensis toxin mRNA as a cause of poor expression in plants." Plant Physiology 117(4): 1445-61. Download.