Peptidyl Prolyl Cis-Trans Isomerases (PPIs)
Xaa-Pro peptide bonds: ~10% cis
PPIs catalyze the otherwise slow interconversion
of Xaa-Pro peptide bonds between their cis and
trans conformations; accelerate the folding of
Pro-containing polypeptides.
Two families: cyclophilins and FKBP12 (based on
known inhibitors)
| Previous slide | Next slide | Back to first slide | View graphic version |