PPT Slide

Rationale for Observed Propensities

For a-helix: appears related to the amount of side-chain

hydrophobic surface buried in the protein

For Pro: low a propensity caused by strain

For Gly: low a propensity caused by reduced entropy and

lack of hydrophobic stabilization

For Ala: high a propensity caused by lack of a g substituent;

reduced entropic cost; minimal hydrophobic stabilization