Proliferation and recruitment of neuroblasts

• Confirmation that BrdU incorporation specifically results from SVZ proliferation

• Ara-C (cytosine-_-D-arabinofuranoside)

  • Antimitotic drug inhibits cell proliferation in mouse SVZ

• BrdU co-injected with Ara-C (saline controls) for 12 days after stroke

• Much lower BrdU in

Ara-C-injected animals

• Cell proliferation in SVZ is

responsible for BrdU

immunopositivity

Cell proliferation

BrdU &

Saline

BrdU &

Ara-C

Number of BrdU+ cells

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