Evidence for self-repair following stroke
Neurogenesis is observed in the adult brain
Cells proliferating from SVZ
- Stroke-generated migratory neuroblasts observed in SVZ (Dcx+)
- Neuroblast production can be depressed by shutting down SVZ (Ara-C)
- Some pre-existing (BrdU-) cells have neuroblast characteristics (Dcx+), but majority of Dcx+ cells are newly formed (BrdU+/Dcx+)
But do new neurons move from SVZ to the lesion?