Chia inducted into the National Academy of Inventors!

Hsueh-Chia Chang, the Bayer Professor of Chemical and Biomolecular Engineering, has been named Fellow of the National Academy of Inventors (NAI). The NAI Fellows Program highlights academic inventors who have demonstrated “a highly prolific spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on the quality of life, economic development, and the welfare of society.” Election to NAI Fellow is the highest professional distinction accorded solely to academic inventors.

Announcement

Mei-Chi wins Bergman Prize!

Mei-Chi Shaw, professor in the Department of Mathematics at the University of Notre Dame, has been awarded the Bergman Prize from the American Mathematical Society for her lifelong contribution to several complex variables, partial differential equations, and Cauchy-Riemann geometry.

Award Announcement

Electrokinetics & Biosensing Electrokinetics & Droplets Optics & Plasmonics Nanotechnology

Summary

Our lab focuses on microfluidic and nanofluidic research coupled with electrokinetics, optics, plasmonics and acoustics for biosening applications. We are able to fabricate nanofluidic transistor circuits that exhibit oscillatory, excitatory, inhibitory and hysteretic ion current/voltage features, including memristor logic circuits that allow digital (binary) address of large ionic circuit sensor arrays. We have integrated these ionic and nanofluidic circuits into liquid biopsy platforms that can 1) isolate and sort tumor cells, exosomes, microvesicles, lipoproteins, stress granules and other molecular carriers in the blood or other physiological samples ; 2) lyse the exosomes/lipoproteins and dissociate the protein-RNA complexes to release the RNA/protein biomarkers; 3) isolate the RNAs from inhibitors and concentrate the analyte molecules; and 4) detect and quantify the molecular biomarkers with digital PCR or amplification-free sensors. Optimum integration with an underlying electronic circuit allows us to carry out automated multiplex profiling of a large library of biomarkers with unprecedented selectivity and sensitivity. Along with our medical and biology collaborators, we are validating these platforms for miRNA over-expression in pancreatic, liver, breast, ovarian and lung cancers; for quantifying stress granules and their protein/RNA cargo during cardiomyocyte infarction and ischemia stokes; for antibody selection in immunotherapy by identifying the protein immune check points on the tumor cell exosomes; for monitoring tissue culture morphogenesis etc.