Dr. Crislyn D'Souza-Schorey on Cellular Biology and the Development of Therapeutics in NP-C Disease

Dr. Crislyn D'Souza-Schorey, Associate Professor at UND discussed her research on ADP -ribosylation factor 6 (ARF6), which promotes the invasion and migration of cells in cancer.

Dr. D'Souza-Schorey discussed the use of in vitro cells, biological and chemical assays, as well as mouse models, which provide an avenue for understanding the activity of the ARF6 cell signaling protein in humans. The class used the journal club format to review Dr. D'Souza-Schorey's paper, "Neurodegeneration in Niemann-Pick Type C Disease and Huntington’s Disease: Impact of Defects in Membrane Trafficking" (Schweitzer JK, Krivda JP, D'Souza-Schorey C., 2009).

Teams of students presented figures from this paper, linking images to data and discussing issues with interpretation and levels of evidence. This seminar offered insight into the development of therapeutics in light of differentiated responses among individuals.



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