The Clinical-Translational Seminar Series - Dr. Carole Long -

(Above) Dr. Carole Long, Chief of the NiAID/NIH Laboratory of Malaria and Vector Research's Malaria Immunology Section and Director of the PATH Malaria Vaccine Initiative Growth Inhibition Assay-Reference Center. (Photo: C Stackowicz, 2012)

October 5, 2012. Dr. Long's seminar to CRND faculty and students entitled, "Progress toward development of a malaria vaccine" provided a comprehensive overview of the current status of vaccine development for various stages of malaria infection. Her presentation reviewed considerations for evaluating new vaccine targets and engaged the audience in an intriguing reflection on what is already known about the acquisition of immunity in endemic areas.

Dr. Long applauded the recent progress in vaccine development due to an expansion of funding and new technologies that have accelerated research. Dr. Long cited the significant advance represented in 2011 with the publication of "First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children" by Agnandji et al. (NEJM 365(20); 1863). This publication by a group from the Albert Schweitzer Hospital in Lambarene, Gabon, reports on an ongoing phase 3 study of over 15,000 children in seven African countries with respect to the malaria vaccine RTS,S/AS01. Dr. Long is the director of the PATH Malaria Vaccine Initiative, which together with GlaxoSmithKline Biologicals, is funding this research. Agnandji et al. conclude in their NEJM article: "The RTS,S/AS01 vaccine provided protection against both clinical and severe malaria in African children."

Following her presentation, Dr. Long joined ND graduate students for lunch and a lively informal discussion of her research and the extraordinary scope and achievement of the PATH Malaria Vaccine initiative.





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