MATH 468

Topology

Fall, 2002


TIME: MWF 12:50-01:40 PM.		ROOM: 229 HAYE

INSTRUCTOR: Laurence Taylor
OFFICE:     246 HAYE                    PHONE: 1-7468
EMAIL:      taylor.2@nd.edu

OFFICE HOURS: 3-4 Monday and Tuesday and by appointment

TEXT: When Topology Meets Chemistry by Erica Flapan
Additional material will be supplied by the instructor.


FINAL:   Wednesday, December 18, 2002  4:15-6:15pm in the regular classroom.


This is a course in topological chemistry, in particular the subject of stereoisomers. These are long molecules which can be considered as graphs and how the graph is embedded in three-space profoundly affects the chemical behavior of the compound. Examples range from limonene, which smells either like lemon or like orange depending on the embedding, to Thalidomide, which is a cure for morning sickness in one embedding but causes severe birth defects in another. There also are interesting problems involving DNA.

Since this is a mathematics course we will abstract chemistry questions to questions about the embeddings of graphs into three-space and develop techniques for distinguishing such embeddings. The book concentrates on distinguishing chiral embeddings from non-chiral ones, a central problem in knot theory and its generalizations to graphs. This is an active area of current mathematical research.


Some web links

Topology and DNA.

The Knot Plot Site

Chiral Information Home Page

Chiral Molecules, Structures and Materials

See definition 4

The Chirality of a Knot

Knots on the Web

And so forth and so on.