Michael W. Handlogten, Ana P. Serezani, Mark H. Kaplan, and Basar Bilgicer. A Heterobivalent Ligand Inhibits Mast Cell Degranulation via Selective Inhibition of Allergen-IgE Interactions In Vivo. Journal of Immunology 2014; In Print.

Michael W. Handlogten, Ana P. Serezani, Mark H. Kaplan, and Basar Bilgicer. What potential do heterobivalent inhibitors have for the treatment of severe allergic reactions? Immunotherapy 2014; In Print.


Haihua Xiao, Gavin T. Noble, Jared F. Stefanick, Ruogu Qi, Tanyel Kiziltepe, Xiabin Jing, and Basar Bilgicer. Photosensitive Pt(IV)-azide prodrug-loaded nanoparticles exhibit controlled drug release and enhanced efficacy in vivo. Journal of Controlled Release 2013; In Print.

Gavin T. Noble, Jared Stefanick, Jonathan Ashley, Tanyel Kiziltepe, and Basar Bilgicer. Ligand-Targeted Liposome Design: Challenges and Fundamental Considerations. Trends in Biotechnology 2013; In Print.

Jared Stefanick, Jonathan Ashley, and Basar Bilgicer. Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles Through Increased Peptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length. ACS Nano 2013; In Print.

Michael W. Handlogten, Tanyel Kiziltepe, Ana P. Serezani, Mark H. Kaplan, and Basar Bilgicer. Selective Inhibition of Weak-Affinity Epitope-IgE Interactions via Heterobivalent Inhibitor Design Prevents Mast Cell Degranulation. Nature Chemical Biology 2013; In Print.

Nathan J. Alves, William Cusick, Jared F. Stefanick, Jonathan D. Ashley, Michael W. Handlogten, and Basar Bilgicer. Functionalized liposome purification via Liposome Extruder Purification (LEP). Analyst 2013; DOI: 10.1039/c3an00680h.

Nathan J. Alves, Nur Mustafaoglu, and Basar Bilgicer. Oriented Antibody Immobilization by Site-Specific UV Photocrosslinking of Biotin at the Conserved Nucleotide Binding Site for Enhanced Antigen Detection. Biosensors and Bioelectronics 2013; DOI: 10.1016/j.bios.2013.05.052.

Nathan J. Alves, Matthew M. Champion, Jared F. Stefanick, Michael W. Handlogten, Demetri T. Moustakas, Yunhua Shi, Bryan F. Shaw, Rudolph M. Navari, Tanyel Kiziltepe and Basar Bilgicer. Selective Photocrosslinking of Functional Ligands to Antibodies via the Conserved Nucleotide Binding Site. Biomaterials 2013; DOI: 10.1016/j.biomaterials.2013.03.082.

Michael W. Handlogten, Jared F. Stefanick, Nathan J. Alves and Basar Bilgicer. Non-chromatographic Affinity Precipitation Method for the Purification of Bivalently Active Pharmaceutical Antibodies from Biological Fluids. Analytical Chemistry 2013; DOI: 10.1021/ac4008286.

Haihua Xiao, Jared Stefanick, Xiaoyu Jia, Xiabin Jing, Tanyel Kiziltepe, Yu Zhang, and Basar Bilgicer. Micellar Nanoparticle Formation via Electrostatic Interactions for Delivering Multinuclear Platinum (II) Drugs. ChemmComm 2013; DOI: 10.1039/C3CC39119A.

Jared Stefanick, Jonathan Ashley, Tanyel Kiziltepe, and Basar Bilgicer. A Systematic Analysis of Peptide Linker Length and Liposomal Polyethylene Glycol Coating on Cellular Uptake of Peptide-Targeted Liposomes. ACS Nano 2013 Feb 19; DOI: 10.1021/nn305663e.

Michael W. Handlogten, Tanyel Kiziltepe, and Basar Bilgicer. Design of a Heterotetravalent Synthetic Allergen That Reflects Epitope Heterogeneity and IgE Antibody Variability to Study Mast Cell Degranulation. Biochemical Journal 2013 Jan 1; 449(1):91-9, DOI: 10.1042/BJ20121088.


Nathan J. Alves, Samuel D. Stimple, Michael W. Handlogten, Jonathan D. Ashley, Tanyel Kiziltepe, and Basar Bilgicer. A Small Molecule Based Affinity Chromatography Method for Antibody Purification via Nucleotide Binding Site Targeting. Analytical Chemistry 2012, -, DOI: 10.1021/ac300952r.

Michael W. Handlogten, Tanyel Kiziltepe, Nathan J. Alves, and Basar Bilgicer. Synthetic Allergen Design Reveals the Significance of Moderate Affinity Epitopes in Mast Cell Degranulation. ACS Chemical Biology 2012, -, DOI: 10.1021/cb300193f.

Yunhua Shi, Richard A. Mowery, Jonathan Ashley, Michelle Hentz, Alejandro J. Ramirez, Basar Bilgicer, Hilda Slunt-Brown, David R. Borchelt, and Bryan F. Shaw. Abnormal SDS-PAGE migration of cytosolic proteins can identify domains and mechanisms that control surfactant binding. Protein Science 2012, 21, 1197-1209.

Nathan J. Alves, Tanyel Kiziltepe, and Basar Bilgicer. Oriented Surface Immobilization of Antibodies at the Conserved Nucleotide Binding Site for Enhanced Antigen Detection. Langmuir 2012, 28, 9640-9648.

Tanyel Kiziltepe, Jonathan D. Ashley, Jared M. Stefanick, Yu Meng Qi, Nathan J. Alves, Michael W. Handlogten, Rudolph Navari, and Basar Bilgicer. VLA4 Targeting Multifunctional Nanoparticles Overcome Drug Resistance and Inhibit Tumor Growth in Multiple Myeloma. Blood Cancer Journal 2012, doi:10.1038/bcj.2012.10.

Eric T. Mack, Phillip W. Snyder, Raquel Perez-Castillejos, Başar Bilgiçer, Demetri T. Moustakas, Manish J. Butte, and George M. Whitesides. Dependence of Avidity on Linker Length for a Bivalent Ligand-Bivalent Receptor Model System. J. Am. Chem. Soc. 2012, 134(1), 333-345

Stefanick, J. F.; Kiziltepe, T.; Handlogten, M. W.; Alves, N. J.; Bilgicer, B. Enhancement of Antibody Selectivity via Bicyclic Complex Formation. J. Phys. Chem. Lett. 2012, 3, 598-602.


Michael W Handlogten, Tanyel Kiziltepe, Demetri T Moustakas and Basar Bilgicer. Design of a Heterobivalent Ligand to Inhibit IgE Clustering on Mast Cells. Chemistry and Biology 2011, 18, 1179-1188.


Abhimanyu Paraskar, Shivani Soni, Kenneth T. Chin, Padmaparna Chaudhuri, Katherine W. Muto, Julia Berkowitz, Michael W. Handlogten, Nathan J. Alves, Başar Bilgicer, Daniela M. Dinulescu, Raghunath A. Mashelkar, Shiladitya Sengupta. Harnessing structure‐activity relationship to engineer a novel cisplatin nanoparticle for improved antitumor efficacy. Proc. Natl. Acad. Sci. U.S.A. 2010, 28, 12435-12440.

Bryan F. Shaw, Haribabu Arthanari, Andrew Lee, Armando Durazo, Dominique P. Frueh, Michael P. Pollastri, Basar Bilgicer, Steven P. Gygi, Gerhard Wagner, and George M. Whitesides. Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability. J. Am. Chem. Soc. 2010, 132, 17411-17425.


Basar Bilgicer, Samuel W. Thomas III, Bryan F. Shaw, George K. Kaufman, Vijay M. Krishnamurthy, Lara A. Estroff, Jerry Yang, and George M. Whitesides A Non-Chromatographic Method for the Purification of a Bivalently Active Monoclonal IgG Antibody from Biological Fluids. J. Am. Chem. Soc. 2009, 131, 9361-9367.

The Bilgicer Group, 182 Fitzpatrick Hall, Rm A69, Notre Dame, IN 46556 | Phone: 574.631.1341 | Updated: January 7, 2014