Prenylation: C-terminal tetrapeptide, CaaX ( C = cysteine,
a = aliphatic amino acid, X = any amino acid
Farnesylation: X = Gln, Met or Ser
Geranylgeranylation: X = Leu
Attachment: via a thioether linkage; aaX is excised
proteolytically, and new C-terminus is esterified
with a methyl group
Function of prenylation: intracellular membrane
anchoring of proteins; facilitates protein-protein
interactions
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