Landscape Theory of Protein Folding
Polypeptides fold via a series of conformational
adjustments that reduce their free energy and entropy
until the native state is reached.
There is no single pathway or closely related set
of pathways that a polypeptide must follow in folding
to its native state.
The sequence information specifying a particular
fold is both distributed throughout the polypeptide
chain and highly overdetermined.
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