Background: Magavi et al.
Magavi et al. (Nature 405, 951–955 (2000))
- induced neuronal degradation and examined fate of dividing cells
- chromophore-targeted apoptosis of pyramidal neurons of the cortex induced neurogenesis some reconstitution of damaged area
- 3D laser scanning confocal microscopy confirmed that new cells are not merely closely in close proximity to pre-existing neurons
- pyramidal morphology indicative of long distance projections
- additional labeling was negative for GFAP and MBP (immature markers) new neurons had fully differentiated