Background: Magavi et al.
Cell division can continue after an injury
But, unlike a clinical stroke event, lesion only affected targeted neurons
- Method makes damaged/destroyed neurons the source of the injury, rather than the pathological outcome
- Ignores tissue complexity
All the surounding cells (and precursors they express) are still intact
- Relatively small lesion
- Quiescent, but pre-determined survivors may differentiate with signals from adjacent cells