Results: developmental markers

BrdU injected at days 4-6 (to examine early cell proliferation)

• 2 weeks after injury:

  • 96% of Dcx+ cells were Meis2+
  • 94% of Dcx+ cells were Pbx+

    • Early markers also seen in BrdU- cells (existing pre-injury, on lesion and control side), but stronger in BrdU+ cells

      • Consistent with prior observations of weaker mature expression

• 5 weeks after injury:

  • 42% of BrdU+/NeuN+ cells were BrdU+/DARPP-32+

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