Evidence for self-repair following stroke

• Neurogenesis is observed in the adult brain

• Cells proliferating from SVZ

• New stroke-generated neurons migrate from SVZ to the lesion

• New neurons indicate phenotypic characteristics of the type within the lesion

  • Early markers (Meis2, Pbx) are expressed in new neurons
  • Markers of striatal medium spiny neurons (DARPP-32) are observed in mature stroke-generated cells

• Over what time frame does the maturation process occur?

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