Click on the years below to toggle the list of publications
Click on the years below to toggle the list of publications
2022
2022
An amino acid transporter AAT1 plays a pivotal role in chloroquine resistance evolution in malaria parasites.
Amambua-Ngwa A, Button-Simons KA, Li X, Kumar S, Brenneman KV, Ferrari M, Checkley LA, Halie MT, Shoue DA, McDew-White M, Tindall SM, Reyes A, Delgado E, Dalhoff H, Lerbalestier JK, Amato R, Pearson RD, Taylor AB, Nosten FH, D'Alessandro U, Kwiatkowski D, Cheeseman IH, Kappe SHI, Avery SV, Conway DJ, Vaughan AM, Ferdig MT, Anderson TJC.
bioRVIV. 2022.
Optimizing bulk segregant analysis of drug resistance using Plasmodium falciparum genetic crosses conducted in humanized mice.
Brenneman KV, Li X, Kumar S, Delgado E, Checkley LA, Shoue DA, Reyes A, Abatiiyow BA, Halie MT, Tripura R, Peto T, Lek D, Button-Simons KA, Kappe SH, Dhorda M, Nosten F, Nkhoma SC, Cheeseman IH, Vaughan AM, Ferdig MT, Anderson TJC.
iScience. 2022, 25: 4.
Sources of transcription variation in Plasmodium falciparum.
Turnbull LB, Button-Simons KA, Agbayani N, Ferdig MT.
Journal of Genetics and Genomics. 2022, 965-974.
Cyclical regression covariates remove the major confounding effect of cyclical developmental gene expression with strain-specific drug response in the malaria parasite Plasmodium falciparum.
Foster GJ, Sievert MAC, Button-Simons KA, Vendrely KM, Romero-Severson J, Ferdig MT.
iScience. 2022, 25: 4.
A Malaria Parasite Cross Reveals Genetic Determinants of Plasmodium falciparum Growth in Different Culture Media.
Kumar S, Li X, McDew-White M, Reyes A, Delgado E, Sayeed A, Haile MT, Abatiyow BA, Kennedy SY, Camargo N, Checkley LA, Brenneman KV, Button-Simons KA, Duraisingh M, Cheeseman IH, Kappe SH, Nosten F, Ferdig MT, Vaughan AM, Anderson TJC.
Front. Cell. Infect. Microbiol. 2022, 12.
Synthesis and antimalarial activity of amide and ester conjugates of siderophores and ozonides.
Tiwari R, Checkley LC, Ferdig MT, Vennerstrom JL, Miller MJ.
BioMetals. 2022, 4563.
2021
2021
The power and promise of genetic mapping from Plasmodium falciparum crosses utilizing human liver-chimeric mice.
Button-Simons KA, Kumar S, Camargo N, Haile MT, Jett C, Checkley LA, Kennedy SY, Pinapati RS, Shoue DA, McDew-White M, Li X, Nosten FH, Kappe SH, Anderson TJC, Romero-Severson J, Ferdig MT, Emrich SJ, Vaughan AM, Cheeseman IH.
Communications Biology. 2021, 734.
The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite.
Zhang M, Wang C, Oberstaller J, Thomas P, Otto TD, Casandra D, Boyapalle S, Adapa SR, Xu S, Button-Simons KA, Mayho M, Rayner JC, Ferdig MT, Jiang RHY, Adams JH.
Nature Communications. 2021, 4563.
2020
2020
The extended recovery ring-stage survival assay provides a superior association with patient clearance half-life and increases throughput.
Davis S, Singh PP, Vendrely KM, Shoue DA, Checkley LA, McDew-White M, Button-Simons KA, Cassady Z, Sievert MAC, Foster GJ, Nosten FH, Anderson TJC, Ferdig MT.
Malaria Journal. 2020 19, 54.
2019
2019
Leveraging crowdsourcing to accelerate global health solutions.
Davis S, Button-Simons KA, Bensellak T, Ahsen EM, Checkley L, Foster GF, Su X, Moussa A, Mapiye D, Khoo SK, Nosten F, Anderson TJC, Vendrely K, Bletz J, Yu T, Panji S, Ghouila A, Mulder N, Norman T, Kern S, Meyer P, Stolovitzky G, Ferdig MT, Siwo G.
Nature Biotechnology. 2019 37, 848-850.
Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle.
Li X, Kumar S, McDew-White M, Haile M, Cheeseman IH, Emrich S, Button-Simons KA, Nosten F, Kappe SHI, Ferdig MT, Anderson TJC, Vaughan, AM
PLoS Genetics. 2019 15(10): e1008453.
Pairwise growth competitions identify relative fitness relationships among artemisinin resistant Plasmodium falciparum field isolates.
Tirrell AR, Vendrely KM, Checkley LA, Davis SZ, McDew-White M, Cheeseman IH, Vaughan AM, Nosten F, Anderson TJC, Ferdig MT
Malaria Journal. 2019 18, 295. https://doi.org/10.1186/s12936-019-2934-4.
2018
2018
Altered expression of K13 disrupts DNA replication and repair in Plasmodium falciparum.
Gibbons J, Button-Simons KA, Adapa SR, Li S, Peitsch M, Li S, Zhang M, Liao X, Adams JH, Ferdig MT, Jiang RHJ.
PLoS ONE. 2017 Nov 15;12(11).
Hackathons as a means of accelerating scientific discoveries and knowledge transfer.
Ghoulia A, Siwo GH, Entfellner JBE, Panji S, Button-Simons KA, Davis SZ, Fadlelmola, FM, The DREAM of Malaria Hackathon Participants, Ferdig MT, Mulder N.
Genome Research. 2018 Apr 12;28:1-7.
2017
2017
Simultaneous genome-wide gene expression and transcript isoform profiling in the human malaria parasite.
Turnbull LB, Siwo GH, Button-Simons KA, Tan A, Checkley LA, Painter HJ, Llinás M, Ferdig MT.
PLoS ONE. 2017 Nov 15;12(11).
Antiplasmodial activity of targeted zinc(II)-dipicolylamine complexes.
Rice DR, de Lourdes Betancourt Mendiola M, Murillo-Solano C, Checkley LA, Ferdig MT, Pizarro JC, Smith BD.
Bioorg Med Chem. 2017 May 15;25(10):2754-60.
2016
2016
Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum
Alistair Miles, Zamin Iqbal, Paul Vauterin, Richard Pearson, Susana Campino, Michel Theron, Kelda Gould, Daniel Mead, Eleanor Drury, John O’Brien, Valentin Ruano Rubio, Bronwyn MacInnis, Jonathan Mwangi, Upeka Samarakoon, Lisa Ranford-Cartwright, Michael Ferdig, Karen Hayton, Xin-zhuan Su, Thomas Wellems, Julian Rayner, Gil McVean, Dominic Kwiatkowski.
Genome Res. 2016 Aug 16;26:1–12.
Open source drug discovery with the malaria box compound collection for neglected diseases and beyond.
Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA.
PLoS Pathog. 2016 Jul 28;12(7):e1005763.
Prediction of fine-tuned promoter activity from DNA sequence
Siwo G, Rider A, Tan A, Pinapati R, Emrich S, Chawla N, Ferdig M
F1000 Research. 2016 Feb 11;5:158.
Garcinol inhibits GCN5-mediated lysine acetyltransferase activity and prevents replication of the parasite Toxoplasma gondii.
Jeffers V, Gao H, Checkley LA, Liu Y, Ferdig MT, Sullivan WJ Jr.
Antimicrob Agents Chemother. 2016 Jan 25. pii: AAC.03059-15.
2015
2015
An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparum.
Siwo GH, Smith RS, Tan A, Button-Simons KA, Checkley LA, Ferdig MT.
BMC Genomics. 2015 Dec 4;16(1):1030.
Population structure shapes copy number variation in malaria parasites.
Cheeseman IH, Miller B, Tan JC, Tan A, Nair S, Nkhoma SC, De Donato M, Rodulfo H, Dondorp A, Branch OH, Mesia LR, Newton P, Mayxay M, Amambua-Ngwa A, Conway DJ, Nosten F, Ferdig MT, Anderson TJ.
Mol Biol Evol. 2015 Nov 26. pii: msv282.
Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery.
Pradhan A, Siwo GH, Singh N, Martens B, Balu B, Button-Simons KA, Tan A, Zhang M, Udenze KO, Jiang RH, Ferdig MT, Adams JH, Kyle DE.
Sci Rep. 2015 Nov 6;5:15930.
Guanabenz repurposed as an antiparasitic with activity against acute and latent toxoplasmosis.
Benmerzouga I, Checkley LA, Ferdig MT, Arrizabalaga G, Wek RC, Sullivan WJ Jr.
Antimicrob Agents Chemother. 2015 Nov;59(11):6939-45.
Plasmodium falciparum genetic crosses in a humanized mouse model.
Vaughan AM, Pinapati RS, Cheeseman IH, Camargo N, Fishbaugher M, Checkley LA, Nair S, Hutyra CA, Nosten FH, Anderson TJ, Ferdig MT, Kappe SH.
Nat Methods. 2015 Jul;12(7):631-633.
Functional analysis of sirtuin genes in multiple Plasmodium falciparum strains.
Merrick CJ, Jiang RH, Skillman KM, Samarakoon U, Moore RM, Dzikowski R, Ferdig MT, Duraisingh MT.
PLoS One. 2015 Mar 17;10(3):e0118865.
Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia.
Takala-Harrison S, Jacob CG, Arze C, Cummings MP, Silva JC, Dondorp AM, Fukuda MM, Hien TT, Mayxay M, Noedl H, Nosten F, Kyaw MP, Nhien NT, Imwong M, Bethell D, Se Y, Lon C, Tyner SD, Saunders DL, Ariey F, Mercereau-Puijalon O, Menard D, Newton PN, Khanthavong M, Hongvanthong B, Starzengruber P, Fuehrer HP, Swoboda P, Khan WA, Phyo AP, Nyunt MM, Nyunt MH, Brown TS, Adams M, Pepin CS, Bailey J, Tan JC, Ferdig MT, Clark TG, Miotto O, MacInnis B, Kwiatkowski DP, White NJ, Ringwald P, Plowe CV.
J Infect Dis. 2015 Mar 1;211(5):670-9.
Predicting functional and regulatory divergence of a drug resistance transporter gene in the human malaria parasite.
Siwo GH, Tan A, Button-Simons KA, Samarakoon U, Checkley L, Pinapati RS, Ferdig MT.
BMC Genomics. 2015 Feb 22;16(1):115.
2014
2014
A microarray platform and novel SNP calling algorithm to evaluate Plasmodium falciparum field samples of low DNA quantity.
Jacob CG, Tan JC, Miller BA, Tan A, Takala-Harrison S, Ferdig MT, Plowe CV.
BMC Genomics. 2014 Aug 26;15(1):719.
Networks' characteristics matter for systems biology.
Rider AK, Milenković T, Siwo GH, Pinapati RS, Emrich SJ, Ferdig MT, Chawla NV.
Netw Sci (Camb Univ Press). 2014 Aug;2(2):139-161.
A supervised learning approach to the ensemble clustering of genes.
Rider AK, Siwo G, Emrich SJ, Ferdig MT, Chawla NV.
Int J Data Min Bioinform. 2014;9(2):199-219.
A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum.
Sanchez CP, Liu CH, Mayer S, Nurhasanah A, Cyrklaff M, Mu J, Ferdig MT, Stein WD, Lanzer M.
PLoS Genet. 2014 May 15;10(5):e1004382.
Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs.
Gaji RY, Checkley L, Reese ML, Ferdig MT, Arrizabalaga G.
Antimicrob Agents Chemother. 2014 May;58(5):2598-607.
Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum.
Hrycyna CA, Summers RL, Lehane AM, Pires MM, Namanja H, Bohn K, Kuriakose J, Ferdig M, Henrich PP, Fidock DA, Kirk K, Chmielewski J, Martin RE.
ACS Chem Biol. 2014 Mar 21;9(3):722-30. Epub 2014 Jan 6.
Metabolic QTL analysis links chloroquine resistance in Plasmodium falciparum to impaired hemoglobin catabolism.
Lewis IA, Wacker M, Olszewski KL, Cobbold SA, Baska KS, Tan A, Ferdig MT, Llinás M.
PLoS Genet. 2014 Jan;10(1):e1004085. Epub 2014 Jan 2.
2013
2013
A process similar to autophagy is associated with cytocidal chloroquine resistance in Plasmodium falciparum.
Gaviria D, Paguio MF, Turnbull LB, Tan A, Siriwardana A, Ghosh D, Ferdig MT, Sinai AP, Roepe PD.
PLoS One. 2013 Nov 20;8(11):e79059.
Inferring gene expression from ribosomal promoter sequences, a crowdsourcing approach.
Meyer P, Siwo G, Zeevi D, Sharon E, Norel R; DREAM6 Promoter Prediction Consortium, Segal E, Stolovitzky G.
Genome Res. 2013 Oct 4.
An apicoplast localized ubiquitylation system is required for the import of nuclear-encoded plastid proteins.
Agrawal S, Chung DW, Ponts N, van Dooren GG, Prudhomme J, Brooks CF, Rodrigues EM, Tan JC, Ferdig MT, Striepen B, Le Roch KG.
PLos Pathog. 2013 Jun;9(6):e1003426. Epub 2013 Jun 13.
Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum.
Heinberg A, Siu E, Stern C, Lawrence EA, Ferdig MT, Deitsch KW, Kirkman LA.
Mol Microbiol. 2013 May;88(4): 702-12. Epub 2013 Apr 24.
2012
2012
Mutation in the Plasmodium falciparum CRT protein determines the stereospecific activity of antimalarial cinchona alkaloids.
Griffin CE, Hoke JM, Samarakoon U, Duan J, Mu J, Ferdig MT, Warhurst DC, Cooper RA.
Antimicrob Agents Chemother. 2012 Oct; 56(10):5356-64
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing.
Manske M, Miotto O, Campino S, Auburn S, Almagro-Garcia J, Maslen G, O’Brien J, Djimde A, Doumbo O, Zongo I, Ouedraogo JB, Michon P, Muller I, Siba P, Nzila A, Borrmann S, Kiara SM, Marsh K, Jiang H, Su XZ, Amaratunga C, Fairhurst R, Socheat D, Nosten F, Imwong M, White NJ, Sanders M, Anastasi E, Alcock D, Drury E, Oyola S, Quail MA, Turner DJ, Ruano-Rubio V, Jyothi D, Amenga-Etego L, Hubbart C, Jeffreys A, Rowlands K, Sutherland C, Roper C, Mangano V, Modiano D, Tan JC, Ferdig MT, Amambua-Ngwa A, Conway DJ, Takala-Harrison S, Plowe CV, Rayner JC, Rockett KA, Clark TG, Newbold CI, Berriman M, MacInnis B, Kwiatkowski DP.
Nature. 2012 Jul 19; 487(7407):375-9
Quantification of mutiple infections of Plasmodium falciparum in vitro.
Wacker MA, Turnbull LB, Walker LA, Mount MC, Ferdig MT.
Malar J. 2012 May 30; 11:180.
A major genome region underlying artemisinin resistance in malaria.
Cheeseman IH, Miller BA, Nair S, Nkhoma S, Tan A, Tan JC, Al Saai S, Phyo AP, Moo CL, Lwin KM, McGready R, Ashley E, Imwong M, Stepniewska K, Yi P, Dondorp AM, Mayzay M, Newton PN, White NJ, Nosten F, Ferdig MT, Anderson TJ.
Science. 2012 Apr 6; 336(6077):79-82.
Symmetric Epistasis Estimation (SEE) and its application to dissecting interaction map of Plasmodium falciparum.
Huang Y, Siwo G, Wuchty S, Ferdig MT, Przytycka TM.
Mol Biosyst. 2012 Apr; 8(5):1544-52.
2011
2011
Differential association of Plasmodium falciparum NA+/H+ exchanger polymorphism and quinine responses in field- and culture-adapted isolates of Plasmodium falciparum.
Pelleau S, Bertaux L, Briolant S, Ferdig MT, Sinou V, Pradines B, Parzy D, Jambou R.
Antimicrob Agents Chemother. 2011 Dec; 55(12):5834-41.
The landscape of inherited and de novo copy number variants in a Plasmodium falciparum genetic cross.
Samarakoon U, Gonzales JM, Patel JJ, Tan A, Checkley L, Ferdig MT.
BMC Genomics. 2011 Sep 22; 12:457.
Shared molecular strategies of the malaria parasite P. falciparum and the human virus HIV-1.
Wuchty S, Siwo GH, Ferdig MT.
Mol Cell Proteomics. 2011 May 17.
An optimized microarray platform for assaying genomic variation in Plasmodium falciparum field populations.
Tan JC, Miller BA, Tan A, Patel JJ, Cheeseman IH, Anderson TJ, Manske M, Maslen G, Kwiatkowski DP, Ferdig MT.
Genomic Biol. 2011 Apr 8;12(4):R35.
High-throughput 454 resequencing for allele discovery and recombination mapping in Plasmodium falciparum.
Samarakoon U, Regier A, Tan A, Desany BA, Collins B, Tan JC, Emrich SJ, Ferdig MT.
BMC Genomics. 2011 Feb 17;12:116.
Design, synthesis, and study of a mycobactin-artemisinin conjugate that has selective and potent activity against tuberculosis and malaria.
Miller MJ, Walz AJ, Zhu H, Wu C, Moraski G, Möllmann U, Tristani EM, Crumbliss AL, Ferdig MT, Checkley L, Edwards RL, Boshoff HI.
J Am Chem Soc. 2011 Jan 28.
2010
2010
Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross.
Patel JJ, Thacker D, Tan JC, Pleeter P, Checkley L, Gonzales JM, Deng B, Roepe PD, Cooper RA, Ferdig MT.
Mol Microbiol. 2010 Nov;78(3):770-87.
A statistical approach to finding overlooked genetic associations.
Rider AK, Siwo G, Chawla NV, Ferdig M, Emrich SJ.
BMC Bioinformatics. 2010 Oct 21;11:526.
Quantitative trait loci mapping reveals candidate pathways regulating cell cycle duration in Plasmodium falciparum.
Reilly Ayala HB, Wacker MA, Siwo G, Ferdig MT.
BMC Genomics. 2010 Oct 18;11:577.
Viral organization of human proteins.
Wuchty S, Siwo G, Ferdig MT.
PLoS One. 2010 Aug 25;5(8):e11796.
Variable numbers of tandem repeats in Plasmodium falciparum genes.
Tan JC, Tan A, Checkley L, Honsa CM, Ferdig MT.
J Mol Evol. 2010 Oct;71(4):268-78. Epub 2010 Aug 22.
2009
2009
Gene copy number and malaria biology.
Anderson TJ, Patel J, Ferdig MT.
Trend Parasitol. 2009 Jul;25(7):336-43. Epub 2009 Jun 24. Review.
P. falciparum Na(+)/H(+) exchanger (PfNHE) function and quinine resistance (QNR)
[Reply to: Spillman et al. "Acid extrusion from the intraerythrocytic malaria parasite is not via a Na(+)/H(+) exchanger" Mol. Biochem. Parasitol. 2008 162 (1) 96-99].
Roepe PD, Ferdig MT.
Mol Biochem Parasitol. 2009 Jul;166(1):1-2; author reply 3. Epub 2009 Apr 10.
Graph theoretical approach to study eQTL: a case study of Plasmodium falciparum.
Huang Y, Wuchty S, Ferdig MT, Przytycka TM.
Bioinformatics. 2009 June 15;25(12):i15-20.
Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE.
Nkrumah LJ, Riegelhaupt PM, Moura P, Johnson DJ, Patel J, Hayton K, Ferdig MT, Wellems TE, Akabas MH, Fidock DA.
Mol Biochem Parasitol. 2009 Jun;165(2):122-31. Epub 2009 Jan 30.
Optimizing comparative genomic hybridization probes for genotyping and SNP detection in Plasmodium falciparum.
Tan JC, Patel JJ, Tan A, Blain JC, Albert TJ, Lobo NF, Ferdig MT.
Genomics. 2009 Jun;93(6):543-50.
A comprehensive Plasmodium falciparum protein interaction map reveals a distinct architecture of a core interactome.
Wuchty S, Adams JH, Ferdig MT.
Proteomics. 2009 Apr;9(7):1841-9.
2008
2008
Adaptive copy number evolution in malaria parasites.
Nair S, Miller B, Barends M, Jaidee A, Patel J, Mayxay M, Newton P, Nosten F, Ferdig MT, Anderson TJ.
PLoS Genet. 2008 Oct;4(10):e1000243. Epub 2008 Oct 31.
Regulatory hotspots in the malaria parasite genome dictate transcriptional variation.
Gonzales JM, Patel JJ, Ponmee N, Jiang L, Tan A, Maher SP, Wuchty S, Rathod PK, Ferdig MT.
PLoS Biol. 2008 Sep 30;6(9):e238.
Genome-wide compensatory changes accompany drug-selected mutations in the Plasmodium falciparum crt gene.
Jiang H, Patel JJ, Yi M, Mu J, Ding J, Stephens R, Cooper RA, Ferdig MT, Su XZ.
PLoS One. 2008 Jun 25;3(6):e2484.
2007
2007
Quantitative dissection of clone-specific growth rates in cultured malaria parasites.
Reilly HB, Wang H, Steuter JA, Marx AM, Ferdig MT.
Int J Parasitol. 2007 Dec;37(14):1599-607.
Plasmodium falciparum Na+/H+ exchanger activity and quinine resistance.
Bennett TN, Patel J, Ferdig MT, Roepe PD.
Mol Biochem Parasitol. 2007 May;153(1):48-58.
Genetic crosses in the apicomplexan parasite Cryptosporidium parvum define recombination parameters.
Tanriverdi S, Blain JC, Deng B, Ferdig MT, Widmer G.
Mol Microbiol. 2007 Mar;63(5):1432-9.
Mutations in transmembrane domains 1, 4 and 9 of the Plasmodium falciparum chloroquine resistance transporter alter susceptibility to chloroquine, quinine and quinidine.
Cooper RA, Lane KD, Deng B, Mu J, Patel JJ, Wellems TE, Su X, Ferdig MT.
Mol Microbiol. 2007 Jan;63(1):270-82.
2006
2006
Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum.
Rohrbach P, Sanchez CP, Hayton K, Friedrich O, Patel J, Sidhu AB, Ferdig MT, Fidock DA, Lanzer M.
EMBO J. 2006 Jul 12;25(13):3000-11.
Stable evolutionary signal in a yeast protein interaction network.
Wuchty S, Barabási AL, Ferdig MT.
BMC Evol Biol. 2006 Jan 30;6:8.
Plasmodium research in the postgenomic era.
Duraisingh M, Ferdig MT, Stoeckert CJ, Volkman SK, McGovern VP.
Trends Parasitol. 2006 Jan;22(1):1-4.
2005
2005
pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective.
Cooper RA, Hartwig CL, Ferdig MT.
Acta Trop. 2005 Jun;94(3):170-80.
2004
2004
Dissecting the loci of low-level quinine resistance in malaria parasites.
Ferdig MT, Cooper RA, Mu J, Deng B, Joy DA, Su XZ, Wellems TE.
Mol Microbiol. 2004 May;52(4):985-97.
QTL analysis for discovery of genes involved in drug responses.
Sen S, Ferdig M.
Curr Drug Targets Infect Disord. 2004 Mar;4(1):53-63.
2003
2003
DNA barcoding of parasites and invertebrate disease vectors: what you don't know can hurt you.
Besansky NJ, Severson DW, Ferdig MT.
Trends Parasitol. 2003 Dec;19(12):545-6. Review.
Multiple transporters associated with malaria parasite responses to chloroquine and quinine.
Mu J, Ferdig MT, Feng X, Joy DA, Duan J, Furuya T, Subramanian G, Aravind L, Cooper RA, Wootton JC, Xiong M, Su XZ.
Mol Microbiol. 2003 Aug;49(4):977-89.
2002
2002
Microsatellite analysis in Plasmodium falciparum.
Su XZ, Ferdig MT.
Methods Mol Med. 2002;72:131-6.
Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum.
Wootton JC, Feng X, Ferdig MT, Cooper RA, Mu J, Baruch DI, Magill AJ, Su XZ.
Nature. 2002 Jul 18;418(6895):320-3.
Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and leishmaniasis.
Zhang P, Nicholson DE, Bujnicki JM, Su X, Brendle JJ, Ferdig M, Kyle DE, Milhous WK, Chiang PK.
J Biomed Sci. 2002 Jan-Feb;9(1):34-40.
Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum.
Cooper RA, Ferdig MT, Su XZ, Ursos LM, Mu J, Nomura T, Fujioka H, Fidock DA, Roepe PD, Wellems TE.
Mol Pharmacol. 2002 Jan;61(1):35-42.
2001
2001
2000
2000
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.
Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, Ferdig MT, Ursos LM, Sidhu AB, Naudé B, Deitsch KW, Su XZ, Wootton JC, Roepe PD, Wellems TE.
Mol Cell. 2000 Oct;6(4):861-71.
Microsatellite markers and genetic mapping in Plasmodium falciparum.
Ferdig MT, Su XZ.
Parasitol Today. 2000 Jul;16(7):307-12.
Aedes aegypti dopa decarboxylase: gene structure and regulation.
Ferdig MT, Taft AS, Smartt CT, Lowenberger CA, Li J, Zhang J, Christensen BM.
Insect Mol Biol. 2000 Jun;9(3):231-9.
Toward quantitative genetic analysis of host and parasite traits in the manifestations of Plasmodium falciparum malaria.
Taylor JG, Ferdig MT, Su XZ, Wellems TE.
Curr Opin Genet Dev. 2000 Jun;10(3):314-9.
1999
1999
A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum.
Su X, Ferdig MT, Huang Y, Huynh CQ, Liu A, You J, Wootton JC, Wellems TE.
Science. 1999 Nov 12;286(5443):1351-3.
Genome projects, genetic analysis, and the changing landscape of malaria research.
Wellems TE, Su XZ, Ferdig M, Fidock DA.
Curr Opin Microbiol. 1999 Aug;2(4):415-9.
Insect immunity: molecular cloning, expression, and characterization of cDNAs and genomic DNA encoding three isoforms of insect defensin in Aedes aegypti.
Lowenberger CA, Smartt CT, Bulet P, Ferdig MT, Severson DW, Hoffmann JA, Christensen BM.
Insect Mol Biol. 1999 Feb;8(1):107-18.
1998
1998
Development of a comparative genetic linkage map for Armigeres subalbatus using Aedes aegypti RFLP markers.
Ferdig MT, Taft AS, Severson DW, Christensen BM.
Genome Res. 1998 Jan;8(1):41-7.
1996
1996
Aedes aegypti: induced antibacterial proteins reduce the establishment and development of Brugia malayi.
Lowenberger CA, Ferdig MT, Bulet P, Khalili S, Hoffmann JA, Christensen BM.
Exp Parasitol. 1996 Jul;83(2):191-201.