Nanopore Publications

Protein Sequencing

Timp W, and Timp G, "Beyond Mass Spectrometry, the Next Step in Proteomics" Science Advances, published online 10 January 2020. doi: 10.1126/sciadv.aax8978. Link to publication.

Rigo E, Dong Z, Park JH, Kennendy E, Hokmabadi M, Almonte-Garcia L, Ding L, Aluru N, and Timp G, "Measurements of the Size and Correlations between Ions using an Electrolytic Point Contact" Nature Communications, published online 30 May 2019. doi: 10.1038/s41467-019-10265-2. Link to publication.

Dong Z, Kennedy E, Hokmabadi M, and Timp G, "Discriminating Residue Substitutions in a Single Protein Molecule Using a Sub-nanopore" ACS Nano, published online 24 May 2017. doi: 10.1021/acsnano.6b08452. Link to publication.

Kennedy E, Dong Z, Tennant C, and Timp G, "Reading the primary structure of a protein with 0.07 nm3 resolution using a subnanometre-diameter pore" Nature Nanotechnology, published online 25 July 2016. doi: 10.1038/NNANO.2016.120. Link to publication.

Eisenstein M, "Teaching nanopores to speak protein" Nature Methods 13, 715 (2016) doi: 10.1038/nmeth.3988. Link to publication.

Kolmogorov M, Kennedy E, Dong Z, Timp G, Pevzner P, "Single-Molecule Protein Identification by Sub-Nanopore Sensors" PLOS Computational Biology doi: Link to publication.

Bonislawski A, "Nanopore-Based Proteome Profiling Within Reach, Study Suggests" Genome Web (2017). Link to publication.

Ramsey D, "Nanopore Technology Makes Leap from DNA Sequencing to Identifying Proteins" Jacobs School of Engineering (2017). Link to publication.

Single Cell

Kennedy E, Hokmabadi M, Dong Z, McKelvey K, Nelson EM, Timp G, "Method for Dynamically Detecting Secretions from Single Cells Using a Nanopore" Nanoletters, 2018. doi: 10.1021/acs.nanolett.8b01257. Link to publication.

Kurz V, Tanaka T, Timp G, "Single Cell Transfection with Single Molecule Resolution Using a Synthetic Nanopore" Nanoletters, 2014. doi: 10.1021/nl403789z. Link to publication.

DNA Sequencing

Nelson E, Li H, Timp G, "Direct, Concurrent Measurements of the Forces and Currents Affecting DNA in a Nanopore with Comparable Topography" ACS Nano, 2014. doi:10.1021/nn405331t. Link to publication.

Kurz V, Nelson E, Tanaka T, and Timp G, "Detection of the Secretome and Transfection of a Single Cell Using a Nanopore," ECS Trans. (2014) doi: 10.1149/06416.0015ecst Conference. Link to publication.

Timp W, Nice A, Nelson E, Kurz V, McKelvey K, and Timp G, "Think Small: Nanopores for Sensing and Synthesis," IEEE Access Special Section on Nanobiosensors, (2014) doi: 10.1109/ACCESS.2014.2369506. Link to publication.

Kurz V, Nelson EM, Shim J, Timp G, "Direct Visualization of Single-Molecule Translocations through Synthetic Nanopores Comparable in Size to a Molecule" ACS Nano, 2013. doi: 10.1021/nn400182s. Link to publication.

Nelson EM, Kurz V, Shim J, Timp W, Timp G, "Using a nanopore for single molecule detection and single cell transfection" Analyst RSC, 2012. doi: 10.1039/C2AN35571J. Link to publication.

Mirsiadov U, Comer J, Dimitrov V, Aksimentiev A, Timp G, "Slowing the translocation of double-stranded DNA using a nanopore smaller than the double helix" Nanotechnology, 2010, 21, 395501. doi: 10.1088/0957-4484/21/39/395501. Link to publication.

Mirsiadov U, Wang D, Timp W, Timp G, "Molecular diagnostics for personal medicine using a nanopore", invited, Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology, 2010, 2:4, 367-381. doi: 10.1002/wnan.86. Link to publication.



Timp W, Mirsaidov U, Wang D, Comer J, Aksimentiev A, Timp G, "Nanopore Sequencing: Electrical Measurements of the Code of Life" invited, Transactions on Nanotechnology, 2010, 9:3, 281 - 294. doi: 10.1109/ TNANO.2010.2044418. Link to publication.


Dimitrov V, Mirsaidov U, Wang D, Sorsch T, Mansfield W, Miner J, Klemens F, Cirelli R, Yemenicioglu S, Timp G, "Nanopores in solid-state membranes engineered for single molecule detection" Nanotechnology, 2009. doi: 10.1088/0957-4484/21/6/065502. Link to publication.

Dorvel B, Sigalov G, Zhao Q, Comer J, Dimitrov V, Mirsaidov U, Aksimentiev A, Timp G, "Analyzing the forces binding a restriction endonuclease to DNA using a synthetic nanopore" Nucleic Acids Research, 2009, 1-10. doi:10.1093/nar/gkp317. Link to publication.

Mirsiadov U, Timp W, Zou X, Dimitrov V, Schulten K, Feinberg A, Timp G, "Nanoelectromechanics of Methylated DNA in a Synthetic Nanopore" Biophysics J. Letters, Feb. 2009, 96, 4. doi: 10.1016/j.bpj.2008.12.3760. Link to publication.

Comer J, Dimitrov V, Zhao Q, Timp G, Aksimentiev A, "Microscopic Mechanics of Hairpin DNA Translocation through Sysnthetic Nanopores", Biophys. J. 2009, 96:593-608. doi:10.1016/j.bpj.2008.09.023. Link to publication.

Laser Guided Assembly Publications

Perry N, Kennedy EM, Timp G, "Wiring Together Synthetic Bacterial Consortia to Create a Biological Integrated Circuit", ACS Synthetic Biology 2016, doi:10.1021/acssynbio.6b00002 Link to publication.

Sarveswaran K, Kurz V, Dong Z, Penny S, Tanaka T, Timp G, "Synthetic Capillaries to Control Microscopic Blood Flow", Scientific Reports 2016, doi:10.1038/srep21885 Link to publication.

Nelson EM, Mirsaidov U, Sarveswaran K, Perry N, Kurz V, Timp W, Timp G, "Ecology of a Simple Synthetic Biofilm", The Physical Basis of Bacterial Quorum Communication Biological and Medical Physics, Biomedical Engineering 2015, pp 205-226, doi: 10.1007/978-1-4939-1402-9_11# Link to publication.

Kurz V, Nelson EM, Perry N, Timp W, Timp G, "Epigenetic Memory Emerging from Integrated Transcription Bursts", Biophys. J. 2013, 105, 6. doi: 10.1016/j.bpj.2013.08.010. Link to publication.

Nelson EM, Kurz V, Perry N, Kyrouac D, Timp G, "Biological Noise Abatement: Coordinating the Responses of Autonomous Bacteria to a Fluctuating Environment Using a Stochastic Bistable Switch", ACS Synthet. Biol. 2014,doi: 10.1021/sb400052f Link to publication.

Lin C, Kolossov VL, Tsvid G, Trump L, Henry JJ, Henderson JL, Rund LA, Kenis PJA, Schook LB, Gaskins HR, Timp G, "Imaging in real-time with FRET the redox response of tumorigenic cells to glutathione perturbations in a microscale flow" Integrative Biology, 2010, doi: 10.1039/C0IB00071J. Link to publication.

Timp W, Mirsaidov U, Matsudaira P, Timp G, "Jamming Prokaryotic Cell-to-Cell Communications in a Model Biofilm", Lab Chip, 2009. doi: 10.1039/b810157d. Link to publication.

Mirsaidov U, Timp W, Timp K, Mir M, Matsudaira P, Timp G, "An Optimal Optical Trap for Bacterial Viability", Phys. Rev. E, 2008, 78, 2, 021910. doi: 10.1103/ PhysRevE.78.021910. Link to publication.

Mirsaidov U, Scrimgeour J, Timp W, Timp K, Mir M, Matsudaira P, Timp G, "Live Cell Lithography: Using Optical Tweezers to Create Synthetic Tissue", Lab on a Chip, 2008. doi: 10.1039/B807987K. Link to publication.



Akselrod GM, Timp W, Mirsaidov U, Zhao Q, Li C, Timp R, Timp K, Matsudaira P, Timp G, "Laser-Guided Assembly of Heterotypic 3D Living Cell Microarrays", Biophys. J. 2006 91 (9): 3465-3473. doi: 10.1529/biophysj.106.084079. Link to publication.


Live Cell Imaging Publications

Kennedy E, Nelson E, Tanaka T, Damiano J, Timp G, "Live Bacterial Physiology Visualized with Five-Nanometer Resolution Using Scanning Transmission Electron Microscopy", ACS Nano 2016, doi: 10.1021/acsnano.5b07697 Link to publication.

Kennedy E, Nelson E, Tanaka T, Damiano J, Timp G, "Gene Expression in Electron-Beam-Irradiated Bacteria in Reply to 'Live Cell Electron Microscopy is Probably Impossible'" ACS Nano 2017, doi: 10.1021/acsnano.6b06616. Link to publication.

Nanotransistor Publications

Bareiß M, Ante F, Kälblein D, Jegert G, Jirauschek C, Scarpa G, Fabel B, Nelson EM, Timp G, Zschieschang U, Klauk H, Porod W, Lugli P, “High-Yield Transfer Printing of Metal-Insulator-Metal Nanodiodes” ACS Nano, March 2012, vol. 6, no. 3, 2853-2859. Link to publication.

Dimitrov V, Heng JB, Timp K, Dimauro O, Chan R, Hafez M, Feng J, Sorsch T, Mansfield W, Miner J, Kornblit A, Klemens F, Bower J, Cirelli R, Ferry EJ, Taylor A, Feng M, Timp G, "Small-signal performance and modeling of sub-50nm nMOSFETs with fT above 460-GHz", Solid State Electronics, 2008, 52, 6, 899-908. Link to publication.

Timp G, Bude J, Baumann F, Bourdelle KK, Boone T, Garno J, Ghetti A, Green M, Gossmann H, Kim Y, Kleiman R, Kornblit A, Klemens F, Moccio S, Muller D, Rosamilia J, Silverman P, Sorsch T, Timp W, Tennant D, Tung R, Weir B, "The relentless march of the MOSFET gate oxide thickness to zero", Proceedings Microelectronics Reliability, 2000, 40, 4-5, 557-562. Link to publication.

Muller DA, Sorsch T, Maccio S, Baumann FH, Evans-Lutterodt K, Timp G, "The electronic structure at the atomic scale of ultrathin gate oxides" Nature, 1999, 399:6738, 758-761. Link to publication.

Stem Cell Publications

Li Y, Drnevich J, Akraiko T, Band M, Li D, Wang F, Matoba R, Tanaka TS, "Gene expression profiling reveals the heterogeneous transcriptional activity of Oct3/4 and its possible interaction with Gli2 in mouse embryonic stem cells", Genomics 2013, Link to publication.

Yu P, Xiao S, Xin X, Song C-X, Huang W, McDee D, Tanaka T, Wang T, He C, Zhong S, "Spatiotemporal clustering of the epigenome reveals rules of dynamic gene regulation", Genome Res. 2013, doi:10.1101/gr.144949.112. Link to publication.

Poh Y-C, Chen J, Hong Y, Yi H, Zhang S, Chen J, Wu DC, Wang L, Jia Q, Singh R, Yao W, Tan Y, Tajik A, Tanaka TS and Wang N, "Generation of organized germ layers from a single mouse embryonic stem cell", Nature Communications 5, Article number: 4000 doi:10.1038/ncomms5000. Link to publication.